Leishmanicidal Activity of Betulin Derivatives in <i>Leishmania amazonensis;</i> Effect on Plasma and Mitochondrial Membrane Potential, and Macrophage Nitric Oxide and Superoxide Production

Herein, we evaluated in vitro the anti-leishmanial activity of betulin derivatives in Venezuelan isolates of <i>Leishmania amazonensis</i>, isolated from patients with therapeutic failure. Methods: We analyzed promastigote in vitro susceptibility as well as the cytotoxicity and selectivity of the ev...

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Hlavní autoři:	Wilmer Alcazar, Sami Alakurtti, Maritza Padrón-Nieves, Maija Liisa Tuononen, Noris Rodríguez, Jari Yli-Kauhaluoma, Alicia Ponte-Sucre
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2021-02-01
Edice:	Microorganisms
Témata:	<i>Leishmania</i> betulin derivatives plasma membrane potential mitochondrial membrane potential therapeutic failure drug resistance
On-line přístup:	https://www.mdpi.com/2076-2607/9/2/320
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