Performance comparison of TCR-pMHC prediction tools reveals a strong data dependency

The interaction of T-cell receptors with peptide-major histocompatibility complex molecules (TCR-pMHC) plays a crucial role in adaptive immune responses. Currently there are various models aiming at predicting TCR-pMHC binding, while a standard dataset and procedure to compare the performance of the...

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Hlavní autoři:	Lihua Deng, Cedric Ly, Sina Abdollahi, Yu Zhao, Immo Prinz, Stefan Bonn
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2023-04-01
Edice:	Frontiers in Immunology
Témata:	T-cell receptor (TCR) peptide MHC machine learning/deep learning TCR specificity prediction
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1128326/full
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