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Instillation of a Dry Powder in Nasal Casts: Parameters Influencing the Olfactory Deposition With Uni- and Bi-Directional Devices

Nose-to-brain delivery is a promising way to reach the central nervous system with therapeutic drugs. However, the location of the olfactory region at the top of the nasal cavity complexifies this route of administration. In this study, we used a 3D-printed replica of a nasal cavity (a so-called “na...

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Hlavní autoři: Clément Rigaut, Laura Deruyver, Jonathan Goole, Benoît Haut, Pierre Lambert
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2022-06-01
Edice:Frontiers in Medical Technology
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On-line přístup:https://www.frontiersin.org/articles/10.3389/fmedt.2022.924501/full
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