More time to kill: A longer liver stage increases T cell-mediated protection against pre-erythrocytic malaria

Summary: Liver stage (LS) Plasmodia mature in 2–2.5 days in rodents compared to 5–6 days in humans. Plasmodium-specific CD8+ T cell expansion differs across these varied timespans. To mimic the kinetics of CD8+ T cells of human Plasmodium infection, a two-dose challenge mouse model that achieved 4–5...

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Principais autores:	Naveen Yadav, Chaitra Parthiban, Zachary P. Billman, Brad C. Stone, Felicia N. Watson, Kevin Zhou, Tayla M. Olsen, Irene Cruz Talavera, Annette Mariko Seilie, Anya C. Kalata, Jokichi Matsubara, Melanie J. Shears, Rebekah A. Reynolds, Sean C. Murphy
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2023-12-01
Series:	iScience
Assuntos:	Immunology Hepatology Biochemistry
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S258900422302566X
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