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Population Pharmacokinetic and Pharmacodynamic Modeling for the Prediction of the Extended Amlitelimab Phase 3 Dosing Regimen in Atopic Dermatitis

ABSTRACT Amlitelimab is a fully human, nondepleting, anti‐OX40 ligand monoclonal antibody being investigated for the treatment of moderate‐to‐severe atopic dermatitis (AD) in adults and adolescents. Population pharmacokinetic (PopPK) and pharmacokinetic/pharmacodynamic‐Eczema Area and Severity Index...

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Principais autores: Gilles Tiraboschi, Kim Papp, Thomas Bieber, Stephan Weidinger, Lisa Beck, Chih‐Hung Lee, John T. O'Malley, Karl Yen, Charlotte Bernigaud, David Fabre, Fabrice Hurbin
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2025-12-01
Serier:CPT: Pharmacometrics & Systems Pharmacology
Fag:
clinical trials
inflammation
modeling
population pharmacokinetics
population pharmacokinetics‐pharmacodynamics
Online adgang:https://doi.org/10.1002/psp4.70121
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