Inflammasome activation and formation of ASC specks in patients with juvenile idiopathic arthritis

ObjectiveThe formation of large intracellular protein aggregates of the inflammasome adaptor ASC is a hallmark of inflammasome activation and characteristic of autoinflammation. Inflammasome activated cells release the highly proinflammatory cytokine IL-1β in addition to ASC specks into the extracel...

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Detalhes bibliográficos

Principais autores:	Nico Wittmann, Neha Mishra, Jana Gramenz, Daniela Kuthning, Ann-Kathrin Behrendt, Lukas Bossaller, Almut Meyer-Bahlburg
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-03-01
coleção:	Frontiers in Medicine
Assuntos:	autoinflammation inflammasome apoptosis-associated speck-like protein (ASC) flow cytometry – methods juvenile idiopathic arthritis
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fmed.2023.1063772/full
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