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Icaritin inhibits osteoclast differentiation and reduces bone loss by targeting ESR1 to inhibit miR503/RANK pathway

BackgroundPostmenopausal osteoporosis (PMOP) is a prevalent metabolic disorder characterized by pathogenic mechanisms associated with the dysfunction of osteoclasts (OC) and osteoblasts (OB). Icaritin (ICT) is a flavonoid derived from icariin and epimedium, which is a natural product, and has demons...

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Hoofdauteurs: Baoping Xie, Xiaofei Liao, Liuyan Xin, Zhen Xie, Qi Jin, An Li, Hongliang Li, Jinping Li
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2025-09-01
Reeks:Frontiers in Pharmacology
Onderwerpen:
icaritin
osteoclast
MiR-503-5p
estrogen receptor
osteoporosis
Online toegang:https://www.frontiersin.org/articles/10.3389/fphar.2025.1603333/full
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