Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor

Metabotropic glutamate receptors (mGluRs) are class C, synaptic G-protein-coupled receptors (GPCRs) that contain large extracellular ligand binding domains (LBDs) and form constitutive dimers. Despite the existence of a detailed picture of inter-LBD conformational dynamics and structural snapshots o...

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Библиографические подробности

Главные авторы:	Vanessa A Gutzeit, Jordana Thibado, Daniel Starer Stor, Zhou Zhou, Scott C Blanchard, Olaf S Andersen, Joshua Levitz
Формат:	Artigo
Язык:	Inglês
Опубликовано:	eLife Sciences Publications Ltd 2019-06-01
Серии:	eLife
Предметы:	GPCRs glutamate receptor conformational dynamics
Online-ссылка:	https://elifesciences.org/articles/45116
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