Genomics-driven discovery of a biosynthetic gene cluster required for the synthesis of BII-Rafflesfungin from the fungus Phoma sp. F3723

Abstract Background Phomafungin is a recently reported broad spectrum antifungal compound but its biosynthetic pathway is unknown. We combed publicly available Phoma genomes but failed to find any putative biosynthetic gene cluster that could account for its biosynthesis. Results Therefore, we seque...

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Detalhes bibliográficos

Principais autores:	Swati Sinha, Choy-Eng Nge, Chung Yan Leong, Veronica Ng, Sharon Crasta, Mohammad Alfatah, Falicia Goh, Kia-Ngee Low, Huibin Zhang, Prakash Arumugam, Alexander Lezhava, Swaine L. Chen, Yoganathan Kanagasundaram, Siew Bee Ng, Frank Eisenhaber, Birgit Eisenhaber
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2019-05-01
coleção:	BMC Genomics
Assuntos:	Cyclic lipodepsipeptide Biosynthetic gene cluster Combined NRPS/PKS cluster NonRibosomal Peptide Synthetase (NRPS) Adenylation domain Condensation domain
Acesso em linha:	http://link.springer.com/article/10.1186/s12864-019-5762-6
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