Modeling predicts facile release of nitrite but not nitric oxide from the thionitrate CH3SNO2 with relevance to nitroglycerin bioactivation
Abstract Nitroglycerin is a potent vasodilator in clinical use since the late 1800s. It functions as a prodrug that is bioactivated by formation of an enzyme-based thionitrate, E–Cys–NO2. This intermediate reportedly decomposes to release NO and NO2 − but their relative yields remain controversial....
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
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Nature Portfolio
2024-12-01
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| Series: | Scientific Reports |
| Assuntos: | |
| Acceso en liña: | https://doi.org/10.1038/s41598-024-80230-7 |
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