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Abnormal phosphorylation of human LRH1 at Ser510 predicts poor prognosis and promotes cell viability in lung squamous cell carcinoma

Abstract The nuclear receptor liver receptor homolog 1 (LRH1)/NR5A2 is aberrantly expressed in diverse cancer types, including liver and lung cancers. Since we previously showed that excessive phosphorylation of human LRH1 at S510 (hLRH1pS510-high) is predictable of hepatocellular carcinoma recurren...

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Principais autores: Hayato Mine, Kotaro Sugimoto, Makoto Kobayashi, Hironori Takagi, Naoyuki Okabe, Satoshi Muto, Yasuyuki Kobayashi, Yuko Hashimoto, Hiroyuki Suzuki, Hideki Chiba
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2025-04-01
Series:BMC Cancer
Assuntos:
Nuclear receptor
NR5A2
Liver receptor homolog 1
Lung cancer
Lung adenocarcinoma
Biomarker
Acceso en liña:https://doi.org/10.1186/s12885-025-14160-6
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