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A consideration of CYP2D6 genetic variations in the Ghanaian population as a potential ‘culprit’ for the tramadol ‘abuse crisis’

Abstract Background Cytochrome P450 2D6 is involved in the metabolism of several important medicines including opioids. Variations in CYP2D6 have been implicated in drug response and according to the Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2D6, dosing for CYP2D6 s...

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Principais autores: Nicholas Ekow Thomford, Susanna Aba Abraham, Samuel Badu Nyarko, Robert Peter Biney
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-01-01
coleção:BMC Medical Genomics
Assuntos:
CYP2D6
Tramadol
Opioid analgesics
Pharmacogenomics
Metabolism
Alleles
Acesso em linha:https://doi.org/10.1186/s12920-023-01773-8
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