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Ablation of Discoidin Domain Receptor 1 Provokes an Osteopenic Phenotype by Regulating Osteoblast/Osteocyte Autophagy and Apoptosis

Discoidin domain receptor 1 (DDR1) is a collagen receptor that belongs to the receptor tyrosine kinase family. We have previously shown that DDR1 plays a crucial role during bone development, resulting in dwarfism and a short stature in osteoblast-specific knockout mice (OKO mice). However, the deta...

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Principais autores: Hsin-Chiao Chou, Sung-Yen Lin, Liang-Yin Chou, Mei-Ling Ho, Shu-Chun Chuang, Tsung-Lin Cheng, Lin Kang, Yi-Shan Lin, Yan-Hsiung Wang, Chun-Wang Wei, Chung-Hwan Chen, Chau-Zen Wang
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2022-09-01
סדרה:Biomedicines
נושאים:
apoptosis
autophagy
bone loss
discoidin domain receptors 1 (DDR1)
osteopenia
גישה מקוונת:https://www.mdpi.com/2227-9059/10/9/2173
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