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Predicting patient-specific response to adaptive therapy in metastatic castration-resistant prostate cancer using prostate-specific antigen dynamics

Abiraterone acetate (AA) has been proven effective for metastatic castration-resistant prostate cancer (mCRPC), and it has been proposed that adaptive AA may reduce toxicity and prolong time to progression, when compared to continuous AA. We developed a simple quantitative model of prostate-specific...

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Autori principali: Renee Brady-Nicholls, Jingsong Zhang, Tian Zhang, Andrew Z. Wang, Robert Butler, Robert A. Gatenby, Heiko Enderling
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2021-09-01
Serie:Neoplasia: An International Journal for Oncology Research
Soggetti:
Prostate cancer
Metastatic
Mathematical
Modeling
Predictive
Adaptive therapy
Accesso online:http://www.sciencedirect.com/science/article/pii/S1476558621000543
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