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Generation of HLA Universal Megakaryocytes and Platelets by Genetic Engineering

Patelet transfusion refractoriness remains a relevant hurdle in the treatment of severe alloimmunized thrombocytopenic patients. Antibodies specific for the human leukocyte antigens (HLA) class I are considered the major immunological cause for PLT transfusion refractoriness. Due to the insufficient...

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Bibliografiska uppgifter
Huvudupphov: Constanca Figueiredo, Rainer Blasczyk
Materialtyp: Artigo
Språk:Inglês
Utgiven: Frontiers Media S.A. 2021-10-01
Serie:Frontiers in Immunology
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Länkar:https://www.frontiersin.org/articles/10.3389/fimmu.2021.768458/full
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