CD93-targeted resveratrol-loaded PLGA nanoparticles remodel CD8⁺ T cell metabolism through AIF-mediated oxidative phosphorylation to overcome lung cancer immunotherapy resistance

Abstract Lung cancer (LC) remains a leading cause of cancer-related mortality worldwide, and the limited efficacy of immunotherapy due to treatment resistance underscores the urgent need for new therapeutic strategies. In the present study, CD93-targeted poly(lactic-co-glycolic acid) (PLGA) nanopart...

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Detalhes bibliográficos

Principais autores:	Zhou Jiang, Yuning Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-03-01
coleção:	Journal of Nanobiotechnology
Assuntos:	Resveratrol CD93-targeted nanoparticles Mitochondrial metabolic reprogramming Oxidative phosphorylation Lung cancer immunotherapy resistance
Acesso em linha:	https://doi.org/10.1186/s12951-026-04216-5
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