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CD101 genetic variants modify regulatory and conventional T cell phenotypes and functions

Summary: We recently reported that the risk of sexually acquired HIV-1 infection is increased significantly by variants in the gene encoding CD101, a protein thought to modify inflammatory responses. Using blood samples from individuals with and without these variants, we demonstrate that CD101 vari...

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Principais autores: Laura E. Richert-Spuhler, Corinne M. Mar, Paurvi Shinde, Feinan Wu, Ting Hong, Evan Greene, Sharon Hou, Katherine Thomas, Raphael Gottardo, Nelly Mugo, Guy de Bruyn, Connie Celum, Jared M. Baeten, Jairam R. Lingappa, Jennifer M. Lund, Anna Wald, Mary S. Campbell, Lawrence Corey, Robert W. Coombs, James P. Hughes, Amalia Magaret, M. Juliana McElrath, Rhoda Morrow, James I. Mullins, David Coetzee, Kenneth Fife, Edwin Were, Max Essex, Joseph Makhema, Elly Katabira, Allan Ronald, Elizabeth Bukusi, Craig Cohen, Saidi Kapiga, Rachel Manongi, Carey Farquhar, Grace John-Stewart, James Kiarie, Sinead Delany-Moretlwe, Helen Rees, Glenda Gray, James McIntyre, Nelly Rwamba Mugo, Deborah Donnell, Lisa Frenkel, Craig W. Hendrix, Elioda Tumwesigye, Patrick Ndase, Eliabeth Bukusi, Jonathan Wangisi, James Campbell, Jordan Tappero
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021-06-01
coleção:Cell Reports Medicine
Assuntos:
CD101
inflammation
immune quiescence
inflammatory homeostasis
T cell
host genetic variation
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2666379121001658
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