Inhibitor of CBP Histone Acetyltransferase Downregulates p53 Activation and Facilitates Methylation at Lysine 27 on Histone H3

Tumor suppressor p53-directed apoptosis triggers loss of normal cells, which contributes to the side-effects from anticancer therapies. Thus, small molecules with potential to downregulate the activation of p53 could minimize pathology emerging from anticancer therapies. Acetylation of p53 by the hi...

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Autores principales:	Adam S. Vincek, Jigneshkumar Patel, Anbalagan Jaganathan, Antonia Green, Valerie Pierre-Louis, Vimal Arora, Jill Rehmann, Mihaly Mezei, Ming-Ming Zhou, Michael Ohlmeyer, Shiraz Mujtaba
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2018-08-01
Colección:	Molecules
Materias:	lysine acetylation transcriptional coactivator CBP histone acetyltransferase cy-C5-curcuminoids p53 acetylation histone acetylation methylation
Acceso en línea:	http://www.mdpi.com/1420-3049/23/8/1930
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