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Long-term functional rescue of trauma-induced vision loss by a novel, small molecule TrkB modulator.

Brain-derived neurotrophic factor (BDNF) signaling through the tropomyosin-related kinase B (TrkB) receptor promotes neuronal growth and survival following an injury. However, its short half-life and pleiotropic effects limit the clinical use of BDNF as a therapy in neurodegenerative disorders. Iden...

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Váldodahkkit: Shweta Modgil, Christopher L Walker, Micah A Chrenek, Hans E Grossniklaus, Frank E McDonald, P Michael Iuvone
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Public Library of Science (PLoS) 2025-01-01
Ráidu:PLoS ONE
Liŋkkat:https://doi.org/10.1371/journal.pone.0320231
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