Connective tissue remodelling is differently modulated by tocilizumab versus methotrexate monotherapy in patients with early rheumatoid arthritis: the AMBITION study

Abstract Objective Associations between rheumatoid arthritis (RA) and effect of treatment at the tissue levels are poorly understood. We investigated the scope of released extracellular matrix (ECM) metabolites as a consequence of tissue remodelling in patients treated with methotrexate (MTX) and to...

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Autori principali:	Patryk J. Drobinski, Anne C. Bay-Jensen, Morten A. Karsdal, Samra Sardar, Anne S. Siebuhr
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2021-01-01
Serie:	Arthritis Research & Therapy
Soggetti:	Tocilizumab (TCZ) Methotrexate (MTX) Rheumatoid arthritis (RA) Biomarkers Tissue remodelling Extracellular matrix (ECM)
Accesso online:	https://doi.org/10.1186/s13075-020-02378-7
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