Generation of genome-edited dogs by somatic cell nuclear transfer

Abstract Background Canine cloning technology based on somatic cell nuclear transfer (SCNT) combined with genome-editing tools such as CRISPR-Cas9 can be used to correct pathogenic mutations in purebred dogs or to generate animal models of disease. Results We constructed a CRISPR-Cas9 vector targeti...

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Detalles Bibliográficos

Principais autores:	Dong-Ern Kim, Ji-Hye Lee, Kuk-Bin Ji, Kang-Sun Park, Tae-Young Kil, Okjae Koo, Min-Kyu Kim
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2022-07-01
Series:	BMC Biotechnology
Assuntos:	Genome-edited dog CRISPR-Cas9 Somatic nuclear transfer DJ-1 knock out
Acceso en liña:	https://doi.org/10.1186/s12896-022-00749-3
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