β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1

Summary: β-glucan is a potent inducer of epigenetic and functional reprogramming of innate immune cells, a process called “trained immunity,” resulting in an enhanced host response against secondary infections. We investigate whether β-glucan exposure confers protection against pulmonary Mycobacteri...

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Bibliographic Details

Main Authors:	Simone J.C.F.M. Moorlag, Nargis Khan, Boris Novakovic, Eva Kaufmann, Trees Jansen, Reinout van Crevel, Maziar Divangahi, Mihai G. Netea
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2020-05-01
Series:	Cell Reports
Subjects:	trained immunity β-glucan tuberculosis Mycobacterium tuberculosis epigenetics monocytes
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124720305878
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