A cyclic undecamer peptide mimics a turn in folded Alzheimer amyloid β and elicits antibodies against oligomeric and fibrillar amyloid and plaques.

The 39- to 42-residue amyloid β (Aβ) peptide is deposited in extracellular fibrillar plaques in the brain of patients suffering from Alzheimer's Disease (AD). Vaccination with these peptides seems to be a promising approach to reduce the plaque load but results in a dominant antibody response direct...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Peter Hoogerhout, Willem Kamphuis, Humphrey F Brugghe, Jacqueline A Sluijs, Hans A M Timmermans, Janny Westdijk, Gijsbert Zomer, Claire J P Boog, Elly M Hol, Germie P J M van den Dobbelsteen
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Public Library of Science (PLoS) 2011-01-01
Serie:	PLoS ONE
Accesso online:	http://europepmc.org/articles/PMC3079747?pdf=render
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!