Single-cell transcriptional regulation and genetic evolution of neuroendocrine prostate cancer

Summary: Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer, with a 10% five-year survival rate. However, little is known about its origin and the mechanisms governing its emergence. Our study characterized ADPC and NEPC in prostate tumors from 7 patients using scRNA-seq. F...

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Detalhes bibliográficos

Principais autores:	Ziwei Wang, Tao Wang, Danni Hong, Baijun Dong, Yan Wang, Huaqiang Huang, Wenhui Zhang, Bijun Lian, Boyao Ji, Haoqing Shi, Min Qu, Xu Gao, Daofeng Li, Colin Collins, Gonghong Wei, Chuanliang Xu, Hyung Joo Lee, Jialiang Huang, Jing Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-07-01
coleção:	iScience
Assuntos:	Cancer systems biology Cancer Transcriptomics
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2589004222008483
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