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Glatiramer–diclofenac nanocomplex enhances remyelination in a mouse model of multiple sclerosis

Abstract Background The hallmark of multiple sclerosis (MS) is neuronal demyelination. Glatiramer acetate (GA) injection is used in the management of MS. Nevertheless, it suffers unacceptable adverse reactions. Alternatively, nose-to-brain drug delivery escapes the blood–brain barrier. Diclofenac so...

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Autori principali: Bander M. Aldhabi, Hani Z. Asfour, Solomon Z. Okbazghi, Mohammed W. Al-Rabia, Nabil A. Alhakamy, Alaa Sirwi, Shaimaa M. Badr-Eldin, Ashraf B. Abdel-Naim, Osama M. Ashour
Natura: Artigo
Lingua:Inglês
Pubblicazione: SpringerOpen 2025-05-01
Serie:Future Journal of Pharmaceutical Sciences
Soggetti:
Multiple sclerosis
Glatiramer
Diclofenac
Nanocomplexation
Nasal formula
Accesso online:https://doi.org/10.1186/s43094-025-00809-3
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