IκBNS-deficiency protects mice from fatal Listeria monocytogenes infection by blunting pro-inflammatory signature in Ly6Chigh monocytes and preventing exaggerated innate immune responses

IκB proteins regulate the inhibition and activation of NF-κB transcription factor complexes. While classical IκB proteins keep NF-κB complexes inactive in the cytoplasm, atypical IκB proteins act on activated NF-κB complexes located in the nucleus. Most of the knowledge regarding the function of IκB...

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Principais autores:	Sarah Frentzel, Andreas Jeron, Alexander Pausder, Olivia Kershaw, Julia Volckmar, Ingo Schmitz, Dunja Bruder
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-12-01
coleção:	Frontiers in Immunology
Assuntos:	IκBNS Listeria monocytogenes in vivo infection hyper-inflammation myeloid cells innate immunity
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1028789/full
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