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Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy

Appropriate regulation of autophagy is crucial for clearing toxic proteins from cells. Defective autophagy results in accumulation of toxic protein aggregates that detrimentally affect cellular function and organismal survival. Here, we report that the microRNA miR-1 regulates the autophagy pathway...

Deskribapen osoa

Gorde:
Egile Nagusiak: Camilla Nehammer, Patrick Ejlerskov, Sandeep Gopal, Ava Handley, Leelee Ng, Pedro Moreira, Huikyong Lee, Shohreh Issazadeh-Navikas, David C Rubinsztein, Roger Pocock
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications Ltd 2019-12-01
Saila:eLife
Gaiak:
microRNA
autophagy
protein aggregation
mammalian cells
human cells
Sarrera elektronikoa:https://elifesciences.org/articles/49930
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