HSPB7 oppositely regulates human mesenchymal stromal cell-derived osteogenesis and adipogenesis

Abstract Background Recent evidence suggests that accumulation of marrow adipose tissue induced by aberrant lineage allocation of bone marrow-derived mesenchymal stromal cells (BMSCs) contributes to the pathophysiologic processes of osteoporosis. Although master regulators of lineage commitment have...

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Autori principali:	Shuang Zhang, Jeroen van de Peppel, Marijke Koedam, Johannes P. T. M. van Leeuwen, Bram C. J. van der Eerden
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2023-05-01
Serie:	Stem Cell Research & Therapy
Soggetti:	Bone marrow-derived mesenchymal stromal cells Osteogenic differentiation Adipogenic differentiation Lineage commitment HSPB7 Activin A
Accesso online:	https://doi.org/10.1186/s13287-023-03361-0
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