Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice
Writing in Science, Al Habsi et al. show that spermidine boosts the efficacy of monoclonal antibodies targeting PD-L1 in aged tumor-bearing mice by enhancing fatty acid oxidation in CD8 T cells. These results open new therapeutic avenues to improve the effectiveness of anticancer immunotherapies in...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Taylor & Francis Group
2022-12-01
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| Serie: | OncoImmunology |
| Soggetti: | |
| Accesso online: | https://www.tandfonline.com/doi/10.1080/2162402X.2022.2146855 |
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