Cannabidiol modulates exosomal miRNA networks to enhance Imatinib mesylate response in chronic myelogenous leukemia

Background/Objectives: Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disease driven by the BCR-ABL1 fusion oncogene. Tyrosine kinase inhibitors (TKIs) such as Imatinib mesylate have dramatically improved patient outcomes, yet resistance remains a major obstacle to long-term effic...

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Principais autores:	Petar Petrov Donchev, Evelina Yordanova Vasileva, Tsvetelina S. Paunova-Krasteva, Svetla Trifonova Danova
Formato:	Artigo
Idioma:	Inglês
Publicado:	KeAi Communications Co., Ltd. 2026-03-01
Series:	Global Medical Genetics
Assuntos:	Chronic myelogenous leukemia (CML) Imatinib resistance Cannabidiol (CBD) Exosomal miRNAs HMGB1 regulation
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2699940426000020
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