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Insights into the binding mode of AS1411 aptamer to nucleolin

AS1411 aptamer can function as a recognition probe to detect the cell surface nucleolin overexpressed in cancer cells, however, little is known about their binding process. This study proposed a feasible binding mode for the first time and provided atomic-level descriptions for the high affinity and...

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Auteurs principaux: Lihua Bie, Yue Wang, Fuze Jiang, Zhen Xiao, Lianjun Zhang, Jing Wang
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2022-10-01
Collection:Frontiers in Molecular Biosciences
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Accès en ligne:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1025313/full
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