SIRT1-Dependent Upregulation of BDNF in Human Microglia Challenged with Aβ: An Early but Transient Response Rescued by Melatonin

Microglia represent a first-line defense in the brain. However, in pathological conditions such as Alzheimer’s disease (AD), a pro-inflammatory switch may occur, leading to loss of protective functions. Using the human microglial cell line HMC3, we showed that exposure to low concentrations of β-amy...

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Detalhes bibliográficos

Principais autores:	Grazia Ilaria Caruso, Simona Federica Spampinato, Giuseppe Costantino, Sara Merlo, Maria Angela Sortino
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-04-01
Colecção:	Biomedicines
Assuntos:	Alzheimer’s disease HMC3 human microglia inflammation microglial switch NF-kB Silent Information Regulator 2 homolog 1
Acesso em linha:	https://www.mdpi.com/2227-9059/9/5/466
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