Single-cell and bulk omics uncover fibroblast heterogeneity and HSPH1 as a key driver in Barrett’s esophagus to esophageal adenocarcinoma progression

Abstract Background Esophageal adenocarcinoma (EAC) is a highly aggressive malignancy with poor prognosis, often evolving from Barrett’s esophagus (BE). Understanding the molecular mechanisms driving this progression is critical for identifying diagnostic biomarkers and therapeutic targets. Methods...

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Detalhes bibliográficos

Principais autores:	Lulong Tao, Yanting Guo, Fang Lu, Changyong Qi, Guoxin Zhang, Jin Yan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-05-01
coleção:	Cancer Cell International
Assuntos:	Esophageal adenocarcinoma Barrett’s esophagus Fibroblast Tumor microenvironment Immunotherapy
Acesso em linha:	https://doi.org/10.1186/s12935-026-04319-x
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