Pathogenic immune response to therapeutic factor VIII: exacerbated response or failed induction of tolerance?
Therapeutic factor VIII is highly immunogenic. Despite intensive research in the last decades, the reasons why 5-30% of patients with hemophilia A (of all severities) develop inhibitory anti-factor VIII antibodies (inhibitors) following replacement therapy remain an enigma. Under physiological condi...
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| Principais autores: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Ferrata Storti Foundation
2019-02-01
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| Serier: | Haematologica |
| Online adgang: | https://haematologica.org/article/view/8765 |
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