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Preparation of a Key Intermediate for the Angiotensin II Antagonist Losartan via Vilsmeier Chloroformylation

A novel preparation of 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde, a key intermediate for the synthesis of the angiotensin II antagonist Losartan potassium, via Vilsmeier chloroformylation of imidazolinone is described.

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Bibliografiske detaljer
Hovedforfatter: Gareth J. Griffiths
Format: Artigo
Sprog:Alemão
Udgivet: Swiss Chemical Society 1997-06-01
Serier:CHIMIA
Online adgang:https://chimia.ch/chimia/article/view/2849
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