The role of Ca2+/calmodulin-dependent protein kinase II and calcineurin in TNF-α-induced myocardial hypertrophy

We investigated whether Ca2+/calmodulin-dependent kinase II (CaMKII) and calcineurin (CaN) are involved in myocardial hypertrophy induced by tumor necrosis factor α (TNF-α). The cardiomyocytes of neonatal Wistar rats (1-2 days old) were cultured and stimulated by TNF-α (100 μg/L)...

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Detalles Bibliográficos

Principais autores:	Gui-Jun Wang, Hong-Xin Wang, Yu-Sheng Yao, Lian-Yi Guo, Pei Liu
Formato:	Artigo
Idioma:	Inglês
Publicado:	Associação Brasileira de Divulgação Científica 2012-11-01
Series:	Brazilian Journal of Medical and Biological Research
Assuntos:	Myocardial hypertrophy Tumor necrosis factor α Calcium Calmodulin-dependent kinase Calcineurin
Acceso en liña:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001100008
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