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Exogenous Indian hedgehog antagonist damages intervertebral discs homeostasis in adult mice

Background: Vismodegib, as an exogenous Indian hedgehog (Ihh) antagonist, has been approved by the Food and Drug Administration (FDA) for the clinical treatment of patients with basal cell carcinoma, and previous observations implicate the potential therapeutic of vismodegib in osteoarthritis treatm...

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Principais autores: Ran Chen, Ya Tan, Yang Li, Junlan Huang, Liang Kuang, Zhenhong Ni, Haiyang Lan, Rui Long, Yangli Xie, Hangang Chen, Xiaoqing Luo, Lin Chen, Ying Tang, Siru Zhou
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-09-01
coleção:Journal of Orthopaedic Translation
Assuntos:
Smoothened inhibitor
Ihh signaling
Intervertebral disc homeostasis
Mice
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2214031X22000948
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