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Effect of dopamine on limbic network connectivity at rest in Parkinson’s disease patients with freezing of gait

Freezing of gait (FOG) in Parkinson’s disease (PD) has a poorly understood pathophysiology, which hinders treatment development. Recent work showed a dysfunctional fronto-striato-limbic circuitry at rest in PD freezers compared to non-freezers in the dopamine “OFF” state. While other studies found t...

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Principais autores: Quek Dione Y. L., Taylor Natasha, Gilat Moran, Lewis Simon J. G., Ehgoetz Martens Kaylena A.
Format: Artigo
Sprog:Inglês
Udgivet: De Gruyter 2024-05-01
Serier:Translational Neuroscience
Fag:
freezing of gait
anxiety
fmri
resting state
parkinson’s disease
amygdala
striatum
emotion
levodopa
resting-state functional connectivity
Online adgang:https://doi.org/10.1515/tnsci-2022-0336
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