Combined neocortical protein and morphological profiling of reactive microglia across Alzheimer’s and Creutzfeldt–Jakob disease

Abstract Recent RNA-sequencing studies have established a reactive molecular signature and highlighted substantial regional diversity of microglia, underscoring their involvement in neurodegenerative proteinopathies. However, the implications of these findings have not been fully elucidated at the p...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Vladyslav Vadymovych Tkach, Nicolai Schou Bager, Signe Regner Michaelsen, Thomas Litman, Knud Josefsen, Bjarne Winther Kristensen, Eva Løbner Lund, Aušrinė Areškevičiūtė
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-11-01
Schriftenreihe:	Acta Neuropathologica Communications
Schlagworte:	Alzheimer’s disease Creutzfeldt–Jakob disease Reactive microglia Regional vulnerability Spatial proteomics Morphology
Online-Zugang:	https://doi.org/10.1186/s40478-025-02163-0
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