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Loss of normal Alzheimer's disease-associated Presenilin 2 function alters antiseizure medicine potency and tolerability in the 6-Hz focal seizure model

IntroductionPatients with early-onset Alzheimer's disease (EOAD) experience seizures and subclinical epileptiform activity, which may accelerate cognitive and functional decline. Antiseizure medicines (ASMs) may be a tractable disease-modifying strategy; numerous ASMs are marketed with well-establis...

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Bibliografische gegevens
Hoofdauteurs: Leanne M. Lehmann, Melissa Barker-Haliski
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2023-08-01
Reeks:Frontiers in Neurology
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Online toegang:https://www.frontiersin.org/articles/10.3389/fneur.2023.1223472/full
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