Cohesin acts as a transcriptional gatekeeper by restraining pause–release to promote processive elongation
Abstract Cohesin organizes 3D chromatin architecture, including promoter–enhancer loops, yet its loss has surprisingly modest effects on steady-state gene expression. We address this paradox by demonstrating that cohesin acts at different stages of transcription in human cells. First, it promotes Po...
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| Principais autores: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Portfolio
2026-08-01
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| Serier: | Nature Communications |
| Online adgang: | https://doi.org/10.1038/s41467-026-76738-3 |
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