Integration of High-Throughput Imaging and Multiparametric Metabolic Profiling Reveals a Mitochondrial Mechanism of Tenofovir Toxicity

Abstract Nephrotoxicity is a major cause of kidney disease and failure in drug development, but understanding of cellular mechanisms is limited, highlighting the need for better experimental models and methodological approaches. Most nephrotoxins damage the proximal tubule (PT), causing functional i...

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Hlavní autoři:	Adam Pearson, Dominik Haenni, Jamal Bouitbir, Matthew Hunt, Brendan A I Payne, Ashwin Sachdeva, Rachel K Y Hung, Frank A Post, John Connolly, Stellor Nlandu-Khodo, Nevena Jankovic, Milica Bugarski, Andrew M Hall
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Physiological Society 2023-01-01
Edice:	Function
Témata:	tenofovir drug toxicity kidney mitochondria imaging
On-line přístup:	https://journals.physiology.org/doi/10.1093/function/zqac065
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