Studying rare variant polygenic risk scores using whole exome sequencing and imputed genotype data
Abstract Rare variant polygenic scores (rvPRS) are developed to improve phenotype prediction, yet a standardized construction protocol remains unavailable. We aim to establish an optimal rvPRS protocol using whole exome sequencing (WES) and imputed genotype (IMP) data from 502,369 UK Biobank partici...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Portfolio
2025-11-01
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| Colección: | Communications Biology |
| Acceso en línea: | https://doi.org/10.1038/s42003-025-09215-0 |
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