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Direct Inhibition of Microglia Activation by Pretreatment With Botulinum Neurotoxin A for the Prevention of Neuropathic Pain

Peripheral injection of botulinum neurotoxin A (BoNT/A) has been demonstrated to have a long-term analgesic effect in treating neuropathic pain. Around peripheral nerves, BoNT/A is taken up by primary afferent neurons and inhibits neuropeptide release. Moreover, BoNT/A could also be retrogradely tra...

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Autors principals: Xiaona Feng, Donglin Xiong, Jie Li, Lizu Xiao, Weijiao Xie, Yunhai Qiu
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021-12-01
Col·lecció:Frontiers in Neuroscience
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Accés en línia:https://www.frontiersin.org/articles/10.3389/fnins.2021.760403/full
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