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Montelukast alleviates neuroinflammation and improves motor functions in the line 61 model of Parkinson's disease: An exploratory study

Parkinson's disease (PD) is a neurodegenerative movement disorder of high global burden. Uncertainties regarding its exact etiology have been hindering the development of curative therapies. As microglia, the brain's immune cells, are suspected to contribute to neurodegeneration by instigating neuro...

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Main Authors: Katharina Strempfl, Marco Zattoni, Heike Mrowetz, Michael S. Unger, Nikolaos Schörghofer, Barbara Altendorfer, Jörg Neddens, Stefanie Flunkert, Birgit Hutter-Paier, Yachao He, Johan Wallin, Rodolphe W. Poupardin, Frank Pietrantonio, Nadine Paiement, Horst Zerbe, Thomas Felder, Per Svenningsson, Ludwig Aigner
Format: Artigo
Language:Inglês
Published: Elsevier 2025-09-01
Series:Neurotherapeutics
Subjects:
Leukotrienes
Repurposing
Parkinson
Alpha-synuclein
Neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S1878747925001680
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