Glycerol Kinase Drives Hepatic de novo Lipogenesis and Triglyceride Synthesis in Nonalcoholic Fatty Liver by Activating SREBP‐1c Transcription, Upregulating DGAT1/2 Expression, and Promoting Glycerol Metabolism

Abstract Glycerol kinase (GK) participates in triglyceride (TG) synthesis by catalyzing glycerol metabolism. Whether GK contributes to nonalcoholic fatty liver (NAFL) is unclear. The expression of hepatic Gk is found to be increased in diet‐induced and genetic mouse models of NAFL and is positively...

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Autors principals:	Shuyu Ouyang, Shu Zhuo, Mengmei Yang, Tengfei Zhu, Shuting Yu, Yu Li, Hao Ying, Yingying Le
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2024-12-01
Col·lecció:	Advanced Science
Matèries:	de novo lipogenesis glycerol kinase nonalcoholic fatty liver disease SREBP‐1c triglyceride
Accés en línia:	https://doi.org/10.1002/advs.202401311
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