Engineering processive DNA polymerases with maximum benefit and minimum cost

DNA polymerases need to be engineered to achieve optimal performance for biotechnological applications, which often require high fidelity replication when using modified nucleotides and when replicating difficult DNA sequences. These tasks are achieved for the bacteriophage T4 DNA polymerase by rep...

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Principais autores:	Linda J. Reha-Krantz, Sandra eWoodgate, Myron F. Goodman
格式:	Artigo
語言:	Inglês
出版:	Frontiers Media S.A. 2014-08-01
叢編:	Frontiers in Microbiology
主題:	translocation modified nucleotides DNA polymerase fidelity DNA dynamics DNA polymerase dynamics DNA polymerase processivity
在線閱讀:	http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00380/full
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