Aortic asprosin overexpression does not ameliorate disease pathophysiology in a murine model of Marfan syndrome

Abstract Marfan syndrome (MFS) is a connective tissue disorder caused by FBN1 mutations, characterised by aortic aneurysms leading to life-threatening dissections. Asprosin is the C-terminal propeptide of fibrillin-1 that was shown to function as a glucogenic hormone with critical implications in va...

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Detalhes bibliográficos

Principais autores:	Prithviraj Manohar Vijaya Shetty, Andrea Matzen, Susanne Hille, Sabine Michalewski, Henrike Witthaus, Marie Noormalal, Fady Marcous, Yousef Morcos, Tarik Bozoglu, Wiebke Sommer, Gregor Warnecke, Christian Kupatt, Andreas H. Wagner, Regina Scherließ, Derk Frank, Gerhard Sengle, Oliver J. Müller, Anca Kliesow Remes
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-06-01
Colecção:	Scientific Reports
Acesso em linha:	https://doi.org/10.1038/s41598-026-59187-2
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