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Prognostic value of nucleotide excision repair and translesion DNA synthesis proteins in muscle-infiltrating bladder carcinoma

Abstract Background Cisplatin (CDDP) remains a key agent in the treatment of muscle-infiltrating bladder carcinoma (MIBC). However, a proportion of MIBC patients do not respond to chemotherapy, which may be caused by the increased repair of CDDP-induced DNA damage. The purpose of this study was to e...

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Main Authors: Patrik Palacka, Andrea Holíčková, Jan Roška, Peter Makovický, Miroslava Vallová, Csaba Biró, Eveline Órásová, Jana Obertová, Jozef Mardiak, Thomas A. Ward, Karol Kajo, Miroslav Chovanec
Format: Artigo
Language:Inglês
Published: BMC 2024-09-01
Series:BMC Cancer
Subjects:
Bladder carcinoma
Muscle-infiltrating bladder carcinoma
Cisplatin
Gemcitabine
DNA damage
Nucleotide excision repair
Online Access:https://doi.org/10.1186/s12885-024-12865-8
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