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Integration of scRNA-seq and ST-seq identifies hyperproliferative RRM2+ cells features and therapeutic targets in gastric cancer

Abstract Background Despite substantial progress in discovering novel therapeutic targets and compounds, cancer hyperproliferative cells (CHCs) play a central role in driving tumor progression in gastric cancer (GC). High-resolution single-cell RNA sequencing (scRNA-seq) integrated with spatial tran...

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Principais autores: Shuai Ping, Xiong Jia, Yanan Tian
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-07-01
coleção:Journal of Translational Medicine
Assuntos:
Single-cell sequencing
Spatial transcriptomics
Gastric cancer
Ferroptosis
Acesso em linha:https://doi.org/10.1186/s12967-025-06847-y
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